I wouldn't recommend it. To drive from anywhere over an hour a way to a venue like Small's would be very disappointing. I mean, it's a decent venue, great sound, small, intimate stage, but it is in downtown Hamtramck which is basically the ghetto, and there is no parking lot, you have to park on the street. Any other venue, I would say go for it.
Edit: I was there last night for Touche Amore/Pianos Become The Teeth and I went into the Liquor Store across the street to get a bottle of water, the whole counter had bullet proof glass. You know you're in a shady area when the liquor store has bullet proof glass. I was scared the entire time that my car was going to be gone when the show was over.